▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

Professional phagocytes have a vast and sophisticated arsenal of microbicidal features.
They are capable of ingesting and destroying invading organisms, and can present …

Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis
infection to pulmonary tuberculosis disease in humans remains limited. To define such …

The interaction between diabetes and major world infections like TB is a major public health
concern because of rapidly rising levels of diabetes. The dual burden of tuberculosis (TB) …

The success of Mycobacterium species as pathogens depends on their ability to maintain an
infection inside the phagocytic vacuole of the macrophage. Although the bacteria are …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Tuberculosis remains one of the major infectious causes of morbidity and mortality in the
world, yet the mechanisms by which macrophages defend against Mycobacterium …

One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …