Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
LPA receptors: subtypes and biological actions
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …
signaling molecule by binding to and activating at least five known G protein–coupled …
An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …
(human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell …
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity
Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7)
have been implicated in key biological and pathophysiological processes, including …
have been implicated in key biological and pathophysiological processes, including …
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
S Liu, M Umezu-Goto, M Murph, Y Lu, W Liu, F Zhang… - Cancer cell, 2009 - cell.com
Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to
mediate a plethora of physiological and pathological activities associated with …
mediate a plethora of physiological and pathological activities associated with …
Structural basis of substrate discrimination and integrin binding by autotaxin
J Hausmann, S Kamtekar, E Christodoulou… - Nature structural & …, 2011 - nature.com
Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2,
ENPP2) is a secreted lysophospholipase D that generates the lipid mediator …
ENPP2) is a secreted lysophospholipase D that generates the lipid mediator …
Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis
N Oikonomou, MA Mouratis, A Tzouvelekis… - American journal of …, 2012 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic form of diffuse lung
disease occurring mainly in older adults. Increased lysophosphatidic acid (LPA) …
disease occurring mainly in older adults. Increased lysophosphatidic acid (LPA) …
[PDF][PDF] Hepatocyte autotaxin expression promotes liver fibrosis and cancer
E Kaffe, A Katsifa, N Xylourgidis, I Ninou… - …, 2017 - Wiley Online Library
Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of
lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like lysophospholipid. Increased …
lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like lysophospholipid. Increased …
Autotaxin and LPA receptor signaling in cancer
AJS Houben, WH Moolenaar - Cancer and Metastasis Reviews, 2011 - Springer
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that
functions as a mitogen and motility factor for many cell types. LPA signals through six …
functions as a mitogen and motility factor for many cell types. LPA signals through six …
Autotaxin in pathophysiology and pulmonary fibrosis
I Ninou, C Magkrioti, V Aidinis - Frontiers in medicine, 2018 - frontiersin.org
Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …