Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …

Long-read sequencing (LRS) technologies have provided extremely powerful tools to
explore genomes. While in the early years these methods suffered technical limitations, they …

Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Concurrent readout of sequence and base modifications from long unamplified DNA
templates by Pacific Biosciences of California (PacBio) single-molecule sequencing …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution map** of these modifications is …

Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is
challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment …

Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …