Many of the diverse functional consequences of activating group 1 metabotropic glutamate
receptors require translation of pre-existing mRNA near synapses. One of these …

Interest in BDNF as an activity-dependent modulator of neuronal structure and function in
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …

Local translation meets protein turnover and plasticity demands at synapses, however, the
location of its energy supply is unknown. We found that local translation in neurons is …

The ability to image RNA identity and location with nanoscale precision in intact tissues is of
great interest for defining cell types and states in normal and pathological biological settings …

MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the
message or inhibit translation. The specific function of most mammalian miRNAs is …

The parts of the genome transcribed by a cell or tissue reflect the biological processes and
functions it carries out. We characterized the features of mammalian tissue transcriptomes at …

The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …

Dendritic spines are the primary recipients of excitatory input in the central nervous system.
They provide biochemical compartments that locally control the signaling mechanisms at …

Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset
excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings …

The selective elimination of axons, dendrites, axon and dendrite branches, and synapses,
without loss of the parent neurons, occurs during normal development of the nervous system …