Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in
a variety of medical settings such as wound closure, surgical sealants, regenerative …

Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

Inflammatory bowel disease (IBD) is a lifelong inflammatory immune mediated disorder,
encompassing Crohn's disease (CD) and ulcerative colitis (UC); however, the cause and …

Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides
physical support to tissues and is essential for normal organ function. In the lung, ECM plays …

Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to
metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical …

In this Review we summarize our current understanding of the biology of mesenchymal cells
of the intestinal lamina propria focusing mainly on fibroblasts and myofibroblasts. The topics …

Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that
leads to substantial suffering for millions of patients. In some patients, the chronic …

A defining hallmark of cancer and cancer development is upregulated angiogenesis. The
vasculature formed in tumors is structurally abnormal, not organized in the conventional …