Annotation and classification of CRISPR-Cas systems
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
Cyclic nucleotide signaling in phage defense and counter-defense
Advances in our understanding of prokaryotic antiphage defense mechanisms in the past
few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a …
few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a …
A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems
Type III CRISPR-Cas systems in prokaryotes provide immunity against invading nucleic
acids through the coordinated degradation of transcriptionally active DNA and its transcripts …
acids through the coordinated degradation of transcriptionally active DNA and its transcripts …
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers
In many prokaryotes, type III clustered regularly interspaced short palindromic repeat
(CRISPR)–CRISPR-associated (Cas) systems detect and degrade invasive genetic …
(CRISPR)–CRISPR-associated (Cas) systems detect and degrade invasive genetic …
Two distant catalytic sites are responsible for C2c2 RNase activities
C2c2, the effector of type VI CRISPR-Cas systems, has two RNase activities—one for cutting
its RNA target and the other for processing the CRISPR RNA (crRNA). Here, we report the …
its RNA target and the other for processing the CRISPR RNA (crRNA). Here, we report the …
CRISPR-mediated adaptive immune systems in bacteria and archaea
Effective clearance of an infection requires that the immune system rapidly detects and
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation
Bacteria and archaea have evolved defense and regulatory mechanisms to cope with
various environmental stressors, including virus attack. This arsenal has been expanded by …
various environmental stressors, including virus attack. This arsenal has been expanded by …
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
Abstract Background The CRISPR-Cas adaptive immunity systems that are present in most
Archaea and many Bacteria function by incorporating fragments of alien genomes into …
Archaea and many Bacteria function by incorporating fragments of alien genomes into …
Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense
Abstract CRISPR-associated Rossmann Fold (CARF) and S MODS-a ssociated and fused to
v arious e ffector d omains (SAVED) are key components of c yclic oligonucleotide-b ased a …
v arious e ffector d omains (SAVED) are key components of c yclic oligonucleotide-b ased a …
A novel interference mechanism by a type IIIB CRISPR‐Cmr module in Sulfolobus
Recent studies on CRISPR‐based adaptive immune systems have revealed extensive
structural and functional diversity of the interference complexes which often coexist …
structural and functional diversity of the interference complexes which often coexist …