Drug delivery for tumor theranostics involves the extensive use of the enhanced permeability
and retention (EPR) effect. Previously, various types of nanomedicines have been …

Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …

Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard
clinical treatment of GBM includes a maximal surgical resection followed by concomitant …

The blood brain barrier (BBB) offers protection to the central nervous system (CNS) by
maintaining homeostasis. Besides restricting the entry of harmful xenobiotics and …

Nanoparticles with multifunctionality are being designed and formulated to overcome
various limitations of drugs as well as conventional drug delivery systems. Engineered …

Introduction: Nanostructured delivery vehicles can address key challenges facing drug
delivery, including the lipophilic nature of therapeutic compounds and their effective …

Integrins are a large family of transmembrane adhesion receptors, which play a key role in
interactions of a cell with the surrounding stroma. Integrins are comprised of non-covalently …

The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …

Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative
treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to …

Background The safe and efficient delivery of chemotherapeutic agents is critical to glioma
therapy. However, chemotherapy for glioma is extremely challenging because the blood …