Neural dedifferentiation in the aging brain

JD Koen, MD Rugg - Trends in cognitive sciences, 2019 - cell.com
Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

Neurocognitive aging and the hippocampus across species

SL Leal, MA Yassa - Trends in neurosciences, 2015 - cell.com
There is extensive evidence that aging is associated with impairments in episodic memory.
Many of these changes have been ascribed to neurobiological alterations to the …

Increased prefrontal activity with aging reflects nonspecific neural responses rather than compensation

AM Morcom, RNA Henson - Journal of Neuroscience, 2018 - jneurosci.org
Elevated prefrontal cortex activity is often observed in healthy older adults despite declines
in their memory and other cognitive functions. According to one view, this activity reflects a …

Healthy ageing reduces the precision of episodic memory retrieval.

SM Korkki, FR Richter, P Jeyarathnarajah… - Psychology and …, 2020 - psycnet.apa.org
Episodic memory declines with older age, but it is unresolved whether this decline reflects
reduced probability of successfully retrieving information from memory, or decreased …

Physical activity improves cognition: possible explanations

B Koščak Tivadar - Biogerontology, 2017 - Springer
Good cognitive abilities (CA) enable autonomy, improve social inclusion and act
preventively. Regular physical activity (PA) reduces the risk of develo** Alzheimer's …

Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

AN Trelle, VA Carr, SA Guerin, MK Thieu, M Jayakumar… - elife, 2020 - elifesciences.org
Age-related episodic memory decline is characterized by striking heterogeneity across
individuals. Hippocampal pattern completion is a fundamental process supporting episodic …

Reduced fidelity of neural representation underlies episodic memory decline in normal aging

L Zheng, Z Gao, X **ao, Z Ye, C Chen, G Xue - Cerebral Cortex, 2018 - academic.oup.com
Emerging studies have emphasized the importance of the fidelity of cortical representation in
forming enduring episodic memory. No study, however, has examined whether there are …

GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness

JD Chamberlain, H Gagnon, P Lalwani… - Neurobiology of …, 2021 - Elsevier
Age-related neural dedifferentiation—a decline in the distinctiveness of neural
representations in the aging brain—has been associated with age-related declines in …

[HTML][HTML] Neural evidence for age-related differences in representational quality and strategic retrieval processes

AN Trelle, RN Henson, JS Simons - Neurobiology of Aging, 2019 - Elsevier
Mounting behavioral evidence suggests that declines in both representational quality and
controlled retrieval processes contribute to episodic memory decline with age. The present …

Contributions of representational distinctiveness and stability to memory performance and age differences

VR Sommer, MC Sander - Aging, Neuropsychology, and Cognition, 2022 - Taylor & Francis
Long-standing theories of cognitive aging suggest that memory decline is associated with
age-related differences in the way information is neurally represented. Multivariate pattern …