Discriminative prediction of mammalian enhancers from DNA sequence

D Lee, R Karchin, MA Beer - Genome research, 2011 - genome.cshlp.org
Accurately predicting regulatory sequences and enhancers in entire genomes is an
important but difficult problem, especially in large vertebrate genomes. With the advent of …

Effective automated feature construction and selection for classification of biological sequences

U Kamath, K De Jong, A Shehu - PloS one, 2014 - journals.plos.org
Background Many open problems in bioinformatics involve elucidating underlying functional
signals in biological sequences. DNA sequences, in particular, are characterized by rich …

Methods, Systems and Devices Comprising Support Vector Machine for Regulatory Sequence Features

M Beer, D Lee - US Patent App. 14/013,920, 2014 - Google Patents
US20140129152A1 - Methods, Systems and Devices Comprising Support Vector Machine
for Regulatory Sequence Features - Google Patents US20140129152A1 - Methods …

EML: a scalable, transparent meta-learning paradigm for big data applications

U Kamath, C Domeniconi, A Shehu… - Innovations in Big Data …, 2019 - Springer
The work presented in this chapter is motivated by two important challenges that arise when
applying ML techniques to big data applications: the scalability of an ML technique as the …

[BOK][B] Predicting mammalian enhancers from DNA sequence

D Lee - 2013 - search.proquest.com
It is widely appreciated that transcriptional regulation plays a central role in most biological
processes. However, our current understanding of the molecular mechanisms by which the …