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[HTML][HTML] The evolution of seasonal influenza viruses
Despite decades of surveillance and pharmaceutical and non-pharmaceutical interventions,
seasonal influenza viruses continue to cause epidemics around the world each year. The …
seasonal influenza viruses continue to cause epidemics around the world each year. The …
Influenza hemagglutinin structures and antibody recognition
Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza
HA promotes viral entry by engaging the receptor and mediating virus–host membrane …
HA promotes viral entry by engaging the receptor and mediating virus–host membrane …
Influenza hemagglutinin and neuraminidase: Yin–Yang proteins coevolving to thwart immunity
Influenza A virions possess two surface glycoproteins—the hemagglutinin (HA) and
neuraminidase (NA)—which exert opposite functions. HA attaches virions to cells by binding …
neuraminidase (NA)—which exert opposite functions. HA attaches virions to cells by binding …
Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin
JJ Skehel, DC Wiley - Annual review of biochemistry, 2000 - annualreviews.org
▪ Abstract Hemagglutinin (HA) is the receptor-binding and membrane fusion glycoprotein of
influenza virus and the target for infectivity-neutralizing antibodies. The structures of three …
influenza virus and the target for infectivity-neutralizing antibodies. The structures of three …
Structural transitions in influenza haemagglutinin at membrane fusion pH
Infection by enveloped viruses involves fusion of their lipid envelopes with cellular
membranes to release the viral genome into cells. For HIV, Ebola, influenza and numerous …
membranes to release the viral genome into cells. For HIV, Ebola, influenza and numerous …
Influenza antigen engineering focuses immune responses to a subdominant but broadly protective viral epitope
Viral glycoproteins are under constant immune surveillance by a host's adaptive immune
responses. Antigenic variation including glycan introduction or removal is among the …
responses. Antigenic variation including glycan introduction or removal is among the …
Role of hemagglutinin cleavage for the pathogenicity of influenza virus
Although human epidemics of influenza occur on nearly an annual basis and result in a
significant number of “excess deaths,” the viruses responsible are not generally considered …
significant number of “excess deaths,” the viruses responsible are not generally considered …
Antibodies to a conserved influenza head interface epitope protect by an IgG subtype-dependent mechanism
Vaccines to generate durable humoral immunity against antigenically evolving pathogens
such as the influenza virus must elicit antibodies that recognize conserved epitopes …
such as the influenza virus must elicit antibodies that recognize conserved epitopes …
Influenza hemagglutinin membrane anchor
Viruses with membranes fuse them with cellular membranes, to transfer their genomes into
cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved …
cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved …
[ספר][B] Immunology and evolution of infectious disease
SA Frank - 2002 - degruyter.com
From HIV to influenza, the battle between infectious agents and the immune system is at the
heart of disease. Knowledge of how and why parasites vary to escape recognition by the …
heart of disease. Knowledge of how and why parasites vary to escape recognition by the …