The cysteinyl leukotrienes—leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene
E4 (LTE4)—are important mediators of human bronchial asthma,,,. Pharmacological studies …

The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC 4, LTD
4, and LTE 4, are thought to be mediated through at least two distinct but related CysLT G …

During neural induction, the 'organizer'of the vertebrate embryo instructs neighbouring
ectodermal cells to become nervous system rather than epidermis. This process is generally …

The flatworm nervous system employs a wide repertoire of neuroactive substances,
including small chemical messengers, the so called classical transmitters, and several types …

Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was
isolated first from porcine spinal cord and later from other species,,,,,,,. It is widely distributed …

ABSTRACT Introduction: Calcium ions (Ca2+) serve as a second messenger or universal
signal transducer implicated in the regulation of a wide range of physiological processes. A …

Melanin-concentrating hormone (MCH) is a 19-aa cyclic neuropeptide originally isolated
from chum salmon pituitaries. Besides its effects on the aggregation of melanophores in fish …

We have isolated and determined the coding sequences of human and mouse orthologs of
the rat orphan G-protein-coupled receptor GPR54. Mouse and rat GPR54 are nearly 95 …

Coelenterazine is an imidazopyrazinone compound (3, 7-dihydroimidazopyrazin-3-one
structure) that is widely distributed in marine organisms and used as a luciferin for various …

We describe in detail a robust, sensitive, and versatile functional assay for G-protein-
coupled receptors (GPCRs) expressed in human embryonic kidney (HEK) 293-EBNA …