The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

Genomic studies have revealed the presence of Ser/Thr kinases and phosphatases in many
bacterial species, although their physiological roles have largely been unclear. Here we …

Metagenomics projects based on shotgun sequencing of populations of micro-organisms
yield insight into protein families. We used sequence similarity clustering to explore proteins …

Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …

Pathogens have evolved strategies to promote their survival by dramatically modifying the
transcriptional profile and protein content of the host cells they infect. Modifications of the …

Reversible protein phosphorylation is a major regulation mechanism of fundamental
biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence …

A cluster of genes encoded by ORFs Rv0014c–Rv0018c in Mycobacterium tuberculosis
encodes candidate cell division proteins RodA and PBPA, a pair of serine/threonine kinases …

FtsZ, a homolog of eukaryotic tubulin, is involved in the process of cell division, particularly
in septum formation in bacteria. The primary amino acid sequences of this protein are fairly …

ABSTRACT Micrococcus luteus (NCTC2665,“Fleming strain”) has one of the smallest
genomes of free-living actinobacteria sequenced to date, comprising a single circular …

The role of protein phosphatases in pathogenic bacteria has been studied extensively over
the last two decades. Ser/Thr and Tyr phosphatases are associated with growth and …