Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Over the past three decades, considerable efforts have been expended on understanding
the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase
(JAK)/STAT signalling cascade and is best known for its essential role in mediating …

Opposing effects of inflammation on cancer have been described. Acute inflammation
usually counteracts cancer development, while chronic inflammation promotes cancer …

Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …

The IFN‐γ/STAT1 immune signaling pathway impacts many homeostatic and pathological
aspects of neurons, beyond its canonical role in controlling intracellular pathogens. Well …

Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …

Interferon-gamma (IFNγ) is a central regulator of the immune response and signals via the
Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) …

Induction of apoptosis is an essential function of p53 as a tumor suppressor. p53 can
activate its downstream targets in a sequence specific manner to induce apoptosis. Most …