[HTML][HTML] Dysregulated FOXM1 signaling in the regulation of cancer stem cells
Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …
been made in understanding the functional and biological plasticity of these elusive …
Forkhead box proteins: tuning forks for transcriptional harmony
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …
fine-tuning the spatial and temporal expression of a broad range of genes both during …
Switching on cilia: transcriptional networks regulating ciliogenesis
Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …
hubs for a variety of signal transduction pathways. Despite having a conserved basic …
FOXM1: A small fox that makes more tracks for cancer progression and metastasis
Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …
pathways associated with normal cell homeostasis and disease conditions. Among cancer …
Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia
X Zhang, M Li, H Ma, X Liu, H Shi, M Li… - Endocrinology, 2017 - academic.oup.com
It is well accepted that Forkhead box protein L2 (Foxl2) and aromatase (Cyp19a1; the
enzyme responsible for estrogen synthesis) are critical for ovarian development in …
enzyme responsible for estrogen synthesis) are critical for ovarian development in …
A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma
Z Liu, Y Zhang, C Shi, X Zhou, K Xu, D Jiao… - Journal of Translational …, 2021 - Springer
Background The tumor immunological microenvironment (TIME) has a prominent impact on
prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by …
prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by …
Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a
MJ Kang, JW Moon, JO Lee, JH Kim… - Journal of Cachexia …, 2022 - Wiley Online Library
Background Skeletal muscle atrophy is a severe condition that involves loss of muscle mass
and quality. Drug intake can also cause muscle atrophy. Biguanide metformin is the first‐line …
and quality. Drug intake can also cause muscle atrophy. Biguanide metformin is the first‐line …
The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis
P Laissue - Molecular cancer, 2019 - Springer
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the
fourth most frequent cause of death having an oncological origin. It has been found that …
fourth most frequent cause of death having an oncological origin. It has been found that …
Forkhead transcription factors in health and disease
Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription
factors that has evolved by gene/genome duplication. FOX family members have undergone …
factors that has evolved by gene/genome duplication. FOX family members have undergone …
Forkhead box transcription factors: double-edged swords in cancer
A plethora of treatment options exist for cancer therapeutics, but many are limited by side
effects and either intrinsic or acquired resistance. The need for more effective targeted …
effects and either intrinsic or acquired resistance. The need for more effective targeted …