Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
With recent approvals for multiple therapeutic antibodies that block cytotoxic T lymphocyte
associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma …
associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma …
5-fluorouracil: mechanisms of action and clinical strategies
Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years,
increased understanding of the mechanism of action of 5-FU has led to the development of …
increased understanding of the mechanism of action of 5-FU has led to the development of …
Lessons from hereditary colorectal cancer
A large body of evidence supports the idea that accumution of mutant APC alleles in affected
kindreds (Groden lated genetic changes underlie the development of neoet al., 1991; …
kindreds (Groden lated genetic changes underlie the development of neoet al., 1991; …
Somatic genomic testing in patients with metastatic or advanced cancer: ASCO provisional clinical opinion
D Chakravarty, A Johnson, J Sklar… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE An ASCO provisional clinical opinion offers timely clinical direction to ASCO's
membership following publication or presentation of potentially practice-changing data from …
membership following publication or presentation of potentially practice-changing data from …
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …
BCL-2 family: regulators of cell death
DT Chao, SJ Korsmeyer - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract An expanding family of BCL-2 related proteins share homology, clustered within
four conserved regions, namely BCL-2 homology (BH1-4) domains, which control the ability …
four conserved regions, namely BCL-2 homology (BH1-4) domains, which control the ability …
DNA mismatch repair in cancer
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent
polymorphism in short repetitive DNA sequences and single nucleotide substitution, as …
polymorphism in short repetitive DNA sequences and single nucleotide substitution, as …
Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer
R Gryfe, H Kim, ETK Hsieh, MD Aronson… - … England Journal of …, 2000 - Mass Medical Soc
Background Colorectal cancer can arise through two distinct mutational pathways:
microsatellite instability or chromosomal instability. We tested the hypothesis that colorectal …
microsatellite instability or chromosomal instability. We tested the hypothesis that colorectal …
A National Cancer Institute workshop on hereditary nonpolyposis colorectal cancer syndrome: meeting highlights and Bethesda guidelines
MA Rodriguez-Bigas, CR Boland… - Journal of the …, 1997 - academic.oup.com
Hereditary nonpolyposis colorectal cancer (HNPCC) is a distinct autosomal dominant
syndrome accounting for approximately 5%–6% of the total colorectal cancer burden with …
syndrome accounting for approximately 5%–6% of the total colorectal cancer burden with …
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
LA Aaltonen, R Salovaara, P Kristo… - … England Journal of …, 1998 - Mass Medical Soc
Background Genetic disorders that predispose people to colorectal cancer include the
polyposis syndromes and hereditary nonpolyposis colorectal cancer. In contrast to the …
polyposis syndromes and hereditary nonpolyposis colorectal cancer. In contrast to the …