Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

The ligands of chemokine receptors 2 and 5 (CCR2 and CCR5, respectively) are associated
with the pathomechanism of neuropathic pain development, but their role in painful diabetic …

Chronic pain and its associated comorbidities are difficult to treat, even when the most
potent analgesic compounds are used. Thus, research on new strategies to effectively …

Neuropathic pain is difficult to cure and is often accompanied by emotional and
psychological changes. Exploring the mechanisms underlying neuropathic pain will help to …

Current investigations underline the important roles of C–C motif ligands in the development
of neuropathic pain; however, their participation in diabetic neuropathy is still undefined …

We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-
NH-CH (CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related …

The involvement of heme oxygenase 1 (HO-1) in the modulation of the antinociceptive
effects of opioids in type 1 diabetes has been demonstrated but the role played by the …

Chemokine signaling has been implicated in the pathogenesis of diabetic neuropathy;
however, the role of chemokine CC motif receptor 4 (CCR4) remains unknown. The goal …

The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity
of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway …