The pulsatile release of GnRH and LH secretion is essential for fertility in all mammals.
Pulses of LH occur approximately every hour in follicular-phase females and every 2 to 3 …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

The mechanism by which arcuate nucleus kisspeptin (ARN KISS) neurons co-expressing
glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

The gonadotropin-releasing hormone (GnRH) pulse is fundamental for mammalian
reproduction: GnRH pulse regimens are needed as therapies for infertile women as …

Increasing evidence accumulated during the past two decades has demonstrated that the
then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin …

Normal reproductive functioning in mammals depends upon gonadotropin-releasing
hormone (GnRH) neurons generating a pulsatile pattern of gonadotropin secretion. The …

Kisspeptin neurons play an essential role in the regulation of fertility through direct
regulation of the GnRH neurons. However, the relative contributions of the two functionally …

Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the
physiological menstrual cycle including the release of gonadotrophins to stimulate follicular …

The understanding of adipose tissue role has evolved from that of a depot energy storage
organ to a dynamic endocrine organ. While genetics, sexual phenotype and sex steroids …