The characterization of mouse models of human disease is essential for understanding the
underlying pathophysiology and develo** new therapeutics. Many diseases are often …

The identification of the mutation causing Huntington's disease (HD) has led to the
generation of a large number of mouse models. These models are used to further enhance …

Huntington's disease is a neurodegenerative disorder, caused by an elongation of CAG
repeats in the huntingtin gene. Mice with an insertion of an expanded polyglutamine repeat …

Huntington's disease (HD)(OMIM 143100) is caused by an expanded CAG repeat tract in the
HTT gene. The inherited CAG length is known to expand further in somatic and germline …

Huntington's disease (HD) is an autosomal-dominant inherited neurological disorder caused
by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a …

Rapid technological advances for the frequent monitoring of health parameters have raised
the intriguing possibility that an individual's genotype could be predicted from phenotypic …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder due to an expanded CAG/polyglutamine repeat in the coding region of the …

Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in
unrelated human causative genes, neurological character, and certain aspects of …

Abstract The Huntingtin (Htt) protein is essential for a wealth of intracellular signaling
cascades and when mutated, causes multifactorial dysregulation of basic cellular processes …

Behavioral testing is a critical step in assessing the validity of rodent models of
neurodegenerative disease, as well as evaluating the efficacy of pharmacological …