Host-directed immunotherapy of viral and bacterial infections: past, present and future
The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
[HTML][HTML] Host-directed therapies for bacterial and viral infections
SHE Kaufmann, A Dorhoi, RS Hotchkiss… - Nature reviews Drug …, 2018 - nature.com
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …
Tuberculous meningitis
Tuberculosis remains a global health problem, with an estimated 10.4 million cases and 1.8
million deaths resulting from the disease in 2015. The most lethal and disabling form of …
million deaths resulting from the disease in 2015. The most lethal and disabling form of …
[HTML][HTML] Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections
Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that
fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to …
fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to …
Tuberculous meningitis: more questions, still too few answers
GE Thwaites, R van Toorn, J Schoeman - The Lancet Neurology, 2013 - thelancet.com
Tuberculous meningitis is especially common in young children and people with untreated
HIV infection, and it kills or disables roughly half of everyone affected. Childhood disease …
HIV infection, and it kills or disables roughly half of everyone affected. Childhood disease …
[HTML][HTML] Therapeutic host-directed strategies to improve outcome in tuberculosis
Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …
has limited efficacy against pulmonary TB disease development and modest protection …
Drug repurposing for the treatment of bacterial and fungal infections
A Miró-Canturri, R Ayerbe-Algaba… - Frontiers in microbiology, 2019 - frontiersin.org
Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …
demands effective solutions; the situation is deemed a global priority by the World Health …
The pathogenesis of tuberculous meningitis
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
Host‐directed therapy to combat mycobacterial infections
Upon infection, mycobacteria, such as Mycobacterium tuberculosis (Mtb) and
nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering …
nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering …
[HTML][HTML] The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes
Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the
cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial …
cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial …