Layer 5 (L5) serves as the main output layer of cortical structures, where long-range
projecting pyramidal neurons broadcast the columnar output to other cortical and …

Executive function is susceptible to aging. How aging impacts the circuit-level computations
underlying executive function remains unclear. Using calcium imaging and optogenetic …

Working memory (WM) and timing are generally considered distinct cognitive functions, but
similar neural signatures have been implicated in both. To explore the hypothesis that WM …

Background The medial prefrontal cortex (mPFC) is involved in complex functions
containing multiple types of neurons in distinct subregions with preferential roles. The …

Dopamine modulates a wide range of cognitive processes in the prefrontal cortex, but the
underlying mechanisms remain unclear. Here, we examined the roles of prefrontal …

Mild cognitive impairment (MCI) reversion refers to patients with MCI who revert from MCI to
a normal cognitive state. Exploring the underlying neuromechanism of MCI reverters may …

Behavior can be remarkably consistent, even over extended time periods, yet whether this is
reflected in stable or 'drifting'neuronal responses to task features remains controversial …

The prefrontal cortex (PFC) is vital for higher cognitive functions and displays neuronal
heterogeneity, with neuronal activity varying significantly across individual neurons. Using …

A large body of evidence indicates functional variations along the hippocampal longitudinal
axis. To investigate whether and how value and outcome processing vary between the …

Post-tetanic Ca2+ release from mitochondria produces presynaptic residual calcium, which
contributes to post-tetanic potentiation. The loss of mitochondria-dependent post-tetanic …