The cell-based model of coagulation remains the basis of our current understanding of
clinical hemostasis and thrombosis. Its advancement on the coagulation cascade model has …

Protein glycosylation is ubiquitous throughout biology. From bacteria to humans, this post
translational modification with sophisticated carbohydrate structures plays a profound role in …

The 2019 coronavirus disease (COVID-19) is the disease caused by SARS-CoV-2 infection.
Although this infection has been shown to affect the respiratory system, a high incidence of …

Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies
found in the Camelidae family as well as cartilaginous fish. Their unique structural and …

Mechanobiology is an emerging field at the interface of biology and mechanics,
investigating the roles of mechanical forces within biomolecules, organelles, cells, and …

Platelet adhesion and activation are essential initial processes of arterial and microvascular
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …

How proteins respond to pulling forces, or protein nanomechanics, is a key contributor to the
form and function of biological systems. Indeed, the conventional view that proteins are able …

Vascular stenosis caused by atherosclerosis instigates activation and aggregation of
platelets, eventually resulting in thrombus formation. Although antiplatelet drugs are …

Purpose To develop a mathematical model for predicting shear-induced von Willebrand
factor (vWF) function modification which can be used to guide ventricular assist devices …

Abstract von Willebrand factor (VWF) is a multimeric protein consisting of covalently linked
monomers, which share an identical domain architecture. Although involved in processes …