The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Decades have passed since the first nanoparticles-base medicine was approved for human
cancer treatment, and the research and development of nanoparticles for drug delivery are …

COVID-19 vaccines have been developed with unprecedented speed which would not have
been possible without decades of fundamental research on delivery nanotechnology. Lipid …

More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …

RNA interference mediated by small interfering RNAs (siRNAs) has been exploited for the
development of therapeutics. siRNAs can be a powerful therapeutic tool because the …

Renal fibrosis is the result of all chronic kidney diseases and is becoming a major global
health hazard. Currently, traditional treatments for renal fibrosis are difficult to meet clinical …

Esophageal cancer (EC) is one of the most lethal cancers in the world, and its morbidity and
mortality rates rank among the top ten in China. Currently, surgical resection, radiotherapy …

Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to
become an essential approach in treating a variety of infectious, hemato-oncological …

Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …