Anatomy, physiology, and pathophysiology of erectile dysfunction

C Gratzke, J Angulo, K Chitaley, Y Dai… - The journal of sexual …, 2010 - academic.oup.com
Introduction Significant scientific advances during the past 3 decades have deepened our
understanding of the physiology and pathophysiology of penile erection. A critical evaluation …

Anatomy, pathophysiology, molecular mechanisms, and clinical management of erectile dysfunction in patients affected by coronary artery disease: a review

G Sangiorgi, A Cereda, D Benedetto, M Bonanni… - Biomedicines, 2021 - mdpi.com
Erectile dysfunction (ED) has been defined as the inability to attain or maintain penile
erection sufficient for successful sexual intercourse. ED carries a notable influence on life …

The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function

A Traish, N Kim - The Journal of Sexual Medicine, 2005 - academic.oup.com
ABSTRACT Traish A, Kim N. The physiological role of androgens in penile erection:
regulation of corpus cavernosum structure and function. J Sex Med 2005; 2: 759–770 It is …

Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence

AM Traish, AT Guay - The journal of sexual medicine, 2006 - academic.oup.com
Androgens are deemed critical for penile‐tissue development, growth, and maintenance of
erectile function, however, their role in erection, especially in humans, remains controversial …

Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial …

J Wang, H Zheng, X Ou, LM Fink… - The American journal of …, 2002 - Elsevier
Microvascular injury is believed to be mechanistically involved in radiation fibrosis, but direct
molecular links between endothelial dysfunction and radiation fibrosis have not been …

Aging and erectile dysfunction

LC Echeverri Tirado, JE Ferrer… - Sexual Medicine …, 2016 - academic.oup.com
Introduction Erectile dysfunction (ED) has been identified as the most common sexual
problem that affects mainly men older than 40 years. According to this, there is a strong …

Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism

J Wang, M Boerma, Q Fu, A Kulkarni, LM Fink… - International Journal of …, 2007 - Elsevier
Purpose: Microvascular injury plays a key role in normal tissue radiation responses. Statins,
in addition to their lipid-lowering effects, have vasculoprotective properties that may …

[HTML][HTML] Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side‐effects after radiation therapy and as …

J Wang, H Zheng, X Ou, CM Albertson, LM Fink… - Journal of Thrombosis …, 2004 - Elsevier
Background: The small bowel is a dose‐limiting normal tissue in radiation therapy of
malignancies in the abdomen and pelvis, as well as an important determinant of survival …

Organization and relative content of smooth muscle cells, collagen and elastic fibers in the corpus cavernosum of rat penis

ANACAD PINHEIRO, WS COSTA, LEM CARDOSO… - The Journal of …, 2000 - Elsevier
PURPOSE: The corpus cavernosum smooth muscle and extracellular matrix are essential
for normal penile erection and are implicated in erectile dysfunction. Although investigations …

Update on corpus cavernosum smooth muscle contractile pathways in erectile function: a role for testosterone?

X Zhang, A Melman, ME DiSanto - The journal of sexual …, 2011 - academic.oup.com
Introduction Normal erectile function (EF) involves a coordinated relaxation of the arteries
that supply the penis and the corpus cavernosum smooth muscle (CCSM), resulting in …