The dynamic pain connectome

A Kucyi, KD Davis - Trends in neurosciences, 2015 - cell.com
Traditionally, studies of how pain and attention modulate one another involved explicit
cognitive-state manipulations. However, emerging evidence suggests that spontaneous …

Best evidence rehabilitation for chronic pain part 5: osteoarthritis

D Rice, P McNair, E Huysmans, J Letzen… - Journal of clinical …, 2019 - mdpi.com
Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which
most commonly affects the joints of the knee, hip, and hand. To date, there are no …

[HTML][HTML] An evaluation of central sensitization in patients with sickle cell disease

CM Campbell, G Moscou-Jackson, CP Carroll, K Kiley… - The Journal of …, 2016 - Elsevier
Central sensitization (CS), nociceptive hyperexcitability known to amplify and maintain
clinical pain, has been identified as a leading culprit responsible for maintaining pain in …

Central and peripheral pain generators in women with chronic pelvic pain: patient centered assessment and treatment

D Hoffman - Current rheumatology reviews, 2015 - ingentaconnect.com
Women with chronic pelvic pain (CPP) often present without obvious cause on imaging
studies, laboratory values or physical exam. Dysfunctional sensory processing in the central …

[HTML][HTML] Online mindfulness-based cognitive behavioral therapy intervention for youth with major depressive disorders: randomized controlled trial

P Ritvo, Y Knyahnytska, M Pirbaglou, W Wang… - Journal of medical …, 2021 - jmir.org
Background Approximately 70% of mental health disorders appear prior to 25 years of age
and can become chronic when ineffectively treated. Individuals between 18 and 25 years …

Advances in targeting central sensitization and brain plasticity in chronic pain

AH Bazzari, FH Bazzari - The Egyptian Journal of Neurology, Psychiatry …, 2022 - Springer
Maladaptation in sensory neural plasticity of nociceptive pathways is associated with various
types of chronic pain through central sensitization and remodeling of brain connectivity …

Optimizing placebo and minimizing nocebo to reduce pain, catastrophizing, and opioid use: a review of the science and an evidence-informed clinical toolkit

BD Darnall, L Colloca - International review of neurobiology, 2018 - Elsevier
Pain, a noxious psychosensory experience, motivates escape behavior to assure protection
and survival. Psychological factors alter the experience and trajectory of pain, as well as …

Non-invasive motor cortex neuromodulation reduces secondary hyperalgesia and enhances activation of the descending pain modulatory network

TJ Meeker, ML Keaser, SA Khan… - Frontiers in …, 2019 - frontiersin.org
Central sensitization is a driving mechanism in many chronic pain patients, and manifests as
hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated …

Can central sensitization after injury persist as an autonomous pain generator? A comprehensive search for evidence

GA Brazenor, GM Malham, PJ Teddy - Pain Medicine, 2022 - academic.oup.com
Objective To conduct a comprehensive search for evidence with regard to whether central
sensitization after an injury can act as a persistent autonomous pain generator after the …

Dynamic changes of functional pain connectome in women with primary dysmenorrhea

TH Wu, CH Tu, HT Chao, WC Li, I Low, CY Chuang… - Scientific reports, 2016 - nature.com
Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain
systems are engaged in pain processing. In light of dynamic communication within and …