Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms
throughout adult life in most of the affected patients. This unfavorable course is associated …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

Neuropsychiatric disease frequently presents with an underlying hyporeactivity or
hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry …

Objectives To provide a quantitative and qualitative synthesis of the available evidence on
the role of Hypothalamic–Pituitary–Adrenal (HPA) axis in the pathophysiology of Bipolar …

Dopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The
dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is …

Sleep disturbance is increasingly recognized as an important, but understudied, mechanism
in the complex and multi-factorial causation of the symptoms and functional disability …

Background: Cortisol and inflammatory markers have been increasingly reported as
abnormal at psychosis onset. The main aim of our study was to investigate the ability of …

The third edition of the hugely successful Handbook of Child and Adolescent Clinical
Psychology incorporates important advances in the field to provide a reliable and accessible …

The experience of childhood trauma (CT) and stressful life events (SLEs) is associated with
subsequent development of a variety of mental health conditions, including psychotic illness …

Prenatal stress is associated with an increased vulnerability to neurodevelopmental
disorders, including autism and schizophrenia. To determine the critical time window when …