Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

RXZ Lu, M Radisic - Bioactive Materials, 2021 - pmc.ncbi.nlm.nih.gov
Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a
significant attention from regulatory agencies regarding their possible adverse health effects …

Immunomodulatory effects of subacute inhalation exposure to copper oxide nanoparticles in house dust mite-induced asthma

S Areecheewakul, A Adamcakova-Dodd… - ACS …, 2023 - ACS Publications
It has been shown that inhalation exposure to copper oxide nanoparticles (CuO NPs) results
in pulmonary inflammation. However, immunomodulatory consequences after CuO NP …

Inflammation increases susceptibility of human small airway epithelial cells to pneumonic nanotoxicity

Z Wu, P Shi, HK Lim, Y Ma, MI Setyawati, D Bitounis… - Small, 2020 - Wiley Online Library
Exposure to inhaled anthropogenic nanomaterials (NM) with dimension< 100 nm has been
implicated in numerous adverse respiratory outcomes. Although studies have identified key …

Comparison of in vitro toxicity of aerosolized engineered nanomaterials using air-liquid interface mono-culture and co-culture models

Y Wang, A Adamcakova-Dodd, BR Steines, X **g… - NanoImpact, 2020 - Elsevier
Airborne engineered nanomaterials (ENMs) can readily enter the human body through
inhalation potentially leading to adverse health effects such as cardiovascular and …

Revealing transport, uptake and damage of polystyrene microplastics using a gut-liver-on-a-chip

Y Wang, J Han, W Tang, X Zhang, J Ding, Z Xu… - Lab on a Chip, 2025 - pubs.rsc.org
Microplastics (MPs) are pervasive pollutants present in various environments. They have the
capability to infiltrate the human gastrointestinal tract through avenues like water and food …

High-throughput screening platform for nanoparticle-mediated alterations of DNA repair capacity

SM Toprani, D Bitounis, Q Huang, N Oliveira, KW Ng… - ACS …, 2021 - ACS Publications
The potential genotoxic effects of engineered nanomaterials (ENMs) may occur through the
induction of DNA damage or the disruption of DNA repair processes. Inefficient DNA repair …

Looking both ways: Electroactive biomaterials with bidirectional implications for dynamic cell–material crosstalk

KK Lee, N Celt, HAM Ardoña - Biophysics Reviews, 2024 - pubs.aip.org
Cells exist in natural, dynamic microenvironmental niches that facilitate biological responses
to external physicochemical cues such as mechanical and electrical stimuli. For excitable …

Evaluation of the toxicity of copper oxide nanoparticles toward pea seeds

A Nagdalian, A Askerova, A Blinov… - World Journal of …, 2024 - environmentaljournals.org
This work considers the use of copper oxide nanoparticles (CuO NPs) for the pre-sowing
treatment of pea seeds as a trace element fertilizer. CuO NPs were chosen since Cu …

Printer center nanoparticles alter the DNA repair capacity of human bronchial airway epithelial cells

D Bitounis, Q Huang, SM Toprani, MI Setyawati… - NanoImpact, 2022 - Elsevier
Nano-enabled, toner-based printing equipment emit nanoparticles during operation. The
bioactivity of these nanoparticles as documented in a plethora of published toxicological …

[HTML][HTML] A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation

B Louis, M Tewary, AW Bremer, C Philippeos, VA Negri… - Acta biomaterialia, 2022 - Elsevier
The balance between stem cell renewal and differentiation is determined by the interplay
between intrinsic cellular controls and extrinsic factors presented by the microenvironment …