Structure, catalytic mechanism, and evolution of the glutathione transferases
RN Armstrong - Chemical research in toxicology, 1997 - ACS Publications
The discovery in 1961 of a catalytic activity for the addition of glutathione (GSH) to 1, 2-
dichloro-4-nitrobenzene in cytosolic extracts of liver (1, 2) initiated three decades of …
dichloro-4-nitrobenzene in cytosolic extracts of liver (1, 2) initiated three decades of …
The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)
Glutathione S-transferases (GSTs) play a pivotal role in the detoxification of foreign
chemicals and toxic metabolites. They were originally termed ligandins because of their …
chemicals and toxic metabolites. They were originally termed ligandins because of their …
Monomer− dimer equilibrium in glutathione transferases: A critical re-examination
Glutathione transferases (GSTs) are dimeric enzymes involved in cell detoxification versus
many endogenous toxic compounds and xenobiotics. In addition, single monomers of GSTs …
many endogenous toxic compounds and xenobiotics. In addition, single monomers of GSTs …
Covalent protein modification: An unignorable factor for bisphenol A-induced hepatotoxicity
X Hu, JL Wu, W Miao, F Long, H Pan… - Environmental …, 2022 - ACS Publications
Covalent modification of proteins by reactive pollutants/metabolites might trigger various
toxicities resulting from the disruption of protein structures and/or functions, which is critical …
toxicities resulting from the disruption of protein structures and/or functions, which is critical …
Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases
L Federici, C Lo Sterzo, S Pezzola, A Di Matteo… - Cancer research, 2009 - AACR
Glutathione S-transferases (GST) constitute a superfamily of enzymes with diversified
functions including detoxification from xenobiotics. In many human cancers, Pi class GST …
functions including detoxification from xenobiotics. In many human cancers, Pi class GST …