The shugoshin/Mei-S332 family are proteins that associate with the chromosomal region
surrounding the centromere (the pericentromere) and that play multiple and distinct roles in …

During meiosis, crossover recombination is essential to link homologous chromosomes and
drive faithful chromosome segregation. Crossover recombination is non-random across the …

Histones serve many purposes in eukaryotic cells in the regulation of diverse genomic
processes, including transcription, replication, DNA repair, and chromatin organization. As …

During mitosis and meiosis, sister chromatid cohesion resists the pulling forces of
microtubules, enabling the generation of tension at kinetochores upon chromosome …

Chromatin structure, transcription, DNA replication, and repair are regulated via locus-
specific incorporation of histone variants and posttranslational modifications that guide …

The exclusive localization of the histone H3 variant CENP-A to centromeres is essential for
accurate chromosome segregation. Ubiquitin-mediated proteolysis helps to ensure that …

Quiescence or G0 is a reversible state in which cells cease division but retain the ability to
resume proliferation. Quiescence occurs in all organisms and is essential for stem cell …

The centromere is located at the primary constriction of condensed chromosomes where it
acts as a platform regulating chromosome segregation. The histone H3 variant CENP-A is …

Centromeres are epigenetically determined nuclear domains strictly required for
chromosome segregation and genome stability. However, the mechanisms regulating …

During chromosome segregation, the spindle assembly checkpoint (SAC) detects errors in
kinetochore-microtubule attachments. Timely activation and maintenance of the SAC until …