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Targeting myosin by blebbistatin derivatives: optimization and pharmacological potential
Blebbistatin is a widely used inhibitor of myosin 2 that enables the study of a broad range of
cytoskeleton-related processes. However, blebbistatin has several limitations hindering its …
cytoskeleton-related processes. However, blebbistatin has several limitations hindering its …
Integrin regulated autoimmune disorders: understanding the role of mechanical force in autoimmunity
The pathophysiology of autoimmune disorders is multifactorial, where immune cell
migration, adhesion, and lymphocyte activation play crucial roles in its progression. These …
migration, adhesion, and lymphocyte activation play crucial roles in its progression. These …
[HTML][HTML] Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic …
Background Peanut allergy (PA) is a complex disease with both environmental and genetic
risk factors. Previously, PA loci were identified in filaggrin (FLG) and HLA in candidate gene …
risk factors. Previously, PA loci were identified in filaggrin (FLG) and HLA in candidate gene …
The potential role of spectrin network in the mechanotransduction of MLO-Y4 osteocytes
XT Wu, LW Sun, X Yang, D Ding, D Han, YB Fan - Scientific reports, 2017 - nature.com
The spectrin is first identified as the main component of erythrocyte membrane skeleton. It is
getting growing attention since being found in multiple nonerythroid cells, providing complex …
getting growing attention since being found in multiple nonerythroid cells, providing complex …
Impaired endothelial cell proliferative, migratory, and adhesive abilities are associated with the slow endothelialization of polycaprolactone vascular grafts implanted …
Most small diameter vascular grafts (inner diameter< 6 mm) evaluation studies are
performed in healthy animals that cannot represent the clinical situation. Herein, an …
performed in healthy animals that cannot represent the clinical situation. Herein, an …
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease
W Li, S Chen, Y Luo, Y **a, Q Ma… - Experimental and …, 2020 - spandidos-publications.com
Parkinson's disease (PD) is a chronic progressive disease that affects the central nervous
system with a variety of symptoms. Although the precise etiology of PD is not yet fully …
system with a variety of symptoms. Although the precise etiology of PD is not yet fully …
Nonmuscle myosin II inhibitors for substance use relapse
C Miller, PR Griffin, TM Kamenecka… - US Patent …, 2023 - Google Patents
The invention can provide compounds, analogs of blebbistatin, effective and selective
inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in …
inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in …
Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
2023-07-06 Assigned to PRINTNET KERESKEDELMI ÉS SZOLGÁLTATÓ KFT., EÖTVÖS
LORÁND TUDOMÁNYEGYETEM reassignment PRINTNET KERESKEDELMI ÉS …
LORÁND TUDOMÁNYEGYETEM reassignment PRINTNET KERESKEDELMI ÉS …
细胞间黏附分子-1 在 CD4+ T 细胞辅助 B 细胞产生抗体中的作用和临床意义
赵倩, 张美玉, 季萍, 汪佳远, 王树军… - 上海交通大学学报 …, 2021 - xuebao.shsmu.edu.cn
目的· 探讨细胞间黏附分子-1 (intercellular adhesion molecule-1, ICAM-1) 在CD4+ T
细胞辅助B 细胞产生抗体中的作用, 以及ICAM-1 与系统性红斑狼疮(systemic lupus …
细胞辅助B 细胞产生抗体中的作用, 以及ICAM-1 与系统性红斑狼疮(systemic lupus …
Role and clinical significance of intercellular adhesion molecule-1 in CD4+ T cells assisting B cells to produce antibodies
Z Qian, M ZHANG, JI **, J WANG… - Journal of Shanghai …, 2021 - xuebao.shsmu.edu.cn
Objective· To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in CD4+ T
cells assisting B cells to produce antibodies, and the correlation between ICAM-1 and …
cells assisting B cells to produce antibodies, and the correlation between ICAM-1 and …