Targeting myosin by blebbistatin derivatives: optimization and pharmacological potential

AÁ Rauscher, M Gyimesi, M Kovács… - Trends in biochemical …, 2018 - cell.com
Blebbistatin is a widely used inhibitor of myosin 2 that enables the study of a broad range of
cytoskeleton-related processes. However, blebbistatin has several limitations hindering its …

Integrin regulated autoimmune disorders: understanding the role of mechanical force in autoimmunity

S Banerjee, R Nara, S Chakraborty… - Frontiers in Cell and …, 2022 - frontiersin.org
The pathophysiology of autoimmune disorders is multifactorial, where immune cell
migration, adhesion, and lymphocyte activation play crucial roles in its progression. These …

[HTML][HTML] Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic …

Y Asai, A Eslami, CD van Ginkel, L Akhabir… - Journal of Allergy and …, 2018 - Elsevier
Background Peanut allergy (PA) is a complex disease with both environmental and genetic
risk factors. Previously, PA loci were identified in filaggrin (FLG) and HLA in candidate gene …

The potential role of spectrin network in the mechanotransduction of MLO-Y4 osteocytes

XT Wu, LW Sun, X Yang, D Ding, D Han, YB Fan - Scientific reports, 2017 - nature.com
The spectrin is first identified as the main component of erythrocyte membrane skeleton. It is
getting growing attention since being found in multiple nonerythroid cells, providing complex …

Impaired endothelial cell proliferative, migratory, and adhesive abilities are associated with the slow endothelialization of polycaprolactone vascular grafts implanted …

H Kang, G Yan, W Zhang, J Xu, J Guo, J Yang, X Liu… - Acta Biomaterialia, 2022 - Elsevier
Most small diameter vascular grafts (inner diameter< 6 mm) evaluation studies are
performed in healthy animals that cannot represent the clinical situation. Herein, an …

Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease

W Li, S Chen, Y Luo, Y **a, Q Ma… - Experimental and …, 2020 - spandidos-publications.com
Parkinson's disease (PD) is a chronic progressive disease that affects the central nervous
system with a variety of symptoms. Although the precise etiology of PD is not yet fully …

Nonmuscle myosin II inhibitors for substance use relapse

C Miller, PR Griffin, TM Kamenecka… - US Patent …, 2023 - Google Patents
The invention can provide compounds, analogs of blebbistatin, effective and selective
inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in …

Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms

A Málnási-Csizmadia, M Gyimesi, A Szabó… - US Patent …, 2023 - Google Patents
2023-07-06 Assigned to PRINTNET KERESKEDELMI ÉS SZOLGÁLTATÓ KFT., EÖTVÖS
LORÁND TUDOMÁNYEGYETEM reassignment PRINTNET KERESKEDELMI ÉS …

细胞间黏附分子-1 在 CD4+ T 细胞辅助 B 细胞产生抗体中的作用和临床意义

赵倩, 张美玉, 季萍, 汪佳远, 王树军… - 上海交通大学学报 …, 2021 - xuebao.shsmu.edu.cn
目的· 探讨细胞间黏附分子-1 (intercellular adhesion molecule-1, ICAM-1) 在CD4+ T
细胞辅助B 细胞产生抗体中的作用, 以及ICAM-1 与系统性红斑狼疮(systemic lupus …

Role and clinical significance of intercellular adhesion molecule-1 in CD4+ T cells assisting B cells to produce antibodies

Z Qian, M ZHANG, JI **, J WANG… - Journal of Shanghai …, 2021 - xuebao.shsmu.edu.cn
Objective· To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in CD4+ T
cells assisting B cells to produce antibodies, and the correlation between ICAM-1 and …