Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

The treatment of bacterial infections suffers from two major problems: spread of multidrug-
resistant (MDR) or extensively drug-resistant (XDR) pathogens and lack of development of …

Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for
bone extracellular matrix formation and resorption. This homeostasis is, in part, altered …

Staphylococcus aureus is a highly successful Gram-positive pathogen capable of causing
both superficial and invasive, life-threatening diseases. Of the invasive disease …

Small colony variants (SCV) of Staphylococcus aureus have been reported as implicated in
chronic infections. Here, we investigated the genomic and transcriptomic changes involved …

Objectives Staphylococcus aureus osteomyelitis often develops to chronicity despite
antimicrobial treatments that have been found to be susceptible in in vitro tests. The complex …

Tetracyclines are a broad-spectrum class of antibiotics that have unclear actions with
potentially lasting effects on bone metabolism. Initially isolated from Streptomyces …

Bone and joint infections are devastating afflictions. Although medical interventions and
advents have improved their care, bone and joint infections still portend dismal outcomes …

Staphylococcus aureus (Sau) plays an important role in human infections occurring in both
the community and hospital settings. Sau-related chronic and relapsing infections are mainly …