Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …

Cells are essential to understanding health and disease, yet traditional models fall short of
modeling and simulating their function and behavior. Advances in AI and omics offer …

Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid …

The prediction of cellular function from a genotype is a fundamental goal in biology. For
metabolism, constraint-based modelling methods systematize biochemical, genetic and …

Understanding how complex phenotypes arise from individual molecules and their
interactions is a primary challenge in biology that computational approaches are poised to …

Over the past decade, a growing community of researchers has emerged around the use of
constraint-based reconstruction and analysis (COBRA) methods to simulate, analyze and …

Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Reconstructed microbial metabolic networks facilitate a mechanistic description of the
genotype–phenotype relationship through the deployment of constraint-based …

INTRODUCTION The generation of biological data is presenting us with one of the most
demanding analysis challenges the world has ever faced, not only in terms of storage and …