Antibody structure and function: the basis for engineering therapeutics
ML Chiu, DR Goulet, A Teplyakov, GL Gilliland - Antibodies, 2019 - mdpi.com
Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …
The structural basis of antibody-antigen recognition
I Sela-Culang, V Kunik, Y Ofran - Frontiers in immunology, 2013 - frontiersin.org
The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …
other components of the immune system to fight pathogens. The six hypervariable loops …
SWISS-MODEL: homology modelling of protein structures and complexes
A Waterhouse, M Bertoni, S Bienert… - Nucleic acids …, 2018 - academic.oup.com
Homology modelling has matured into an important technique in structural biology,
significantly contributing to narrowing the gap between known protein sequences and …
significantly contributing to narrowing the gap between known protein sequences and …
Humanization of an anti-p185HER2 antibody for human cancer therapy.
The murine monoclonal antibody mumAb4D5, directed against human epidermal growth
factor receptor 2 (p185HER2), specifically inhibits proliferation of human tumor cells …
factor receptor 2 (p185HER2), specifically inhibits proliferation of human tumor cells …
Humanized immunoglobulins and methods of making the same
CL Queen, HE Selick - US Patent 6,180,370, 2001 - Google Patents
Novel methods for producing, and compositions of, humanized immunoglobulins having one
or more complementarity determining regions (CDR's) and possible additional amino acids …
or more complementarity determining regions (CDR's) and possible additional amino acids …
Standard conformations for the canonical structures of immunoglobulins
B Al-Lazikani, AM Lesk, C Chothia - Journal of molecular biology, 1997 - Elsevier
A comparative analysis of the main-chain conformation of the L1, L2, L3, H1 and H2
hypervariable regions in 17 immunoglobulin structures that have been accurately …
hypervariable regions in 17 immunoglobulin structures that have been accurately …
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen
Y Chen, C Wiesmann, G Fuh, B Li… - Journal of molecular …, 1999 - Elsevier
The Fab portion of a humanized antibody (Fab-12; IgG form known as rhuMAb VEGF) to
vascular endothelial growth factor (VEGF) has been affinity-matured through …
vascular endothelial growth factor (VEGF) has been affinity-matured through …
Antibody framework residues affecting the conformation of the hypervariable loops
J Foote, G Winter - Journal of molecular biology, 1992 - Elsevier
Rodent monoclonal antibodies have been “humanized” or “reshaped” for therapy by
transplanting the antigen-binding loops from their variable domains onto the β-sheet …
transplanting the antigen-binding loops from their variable domains onto the β-sheet …