Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

PURPOSE Treatment planning for children with neuroblastoma requires accurate
assessment of prognosis. The most recent Children's Oncology Group (COG) risk …

Neuroblastoma is a pediatric tumor of the develo** sympathetic nervous system.
However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the …

Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …

Neuroblastoma, the most frequent solid tumor in infants, shows very diverse outcomes from
spontaneous regression to fatal disease. When these different tumors originate and how …

Half of the children diagnosed with neuroblastoma (NB) have high-risk disease,
disproportionately contributing to overall childhood cancer-related deaths. In addition to …

Rationale: Synergic reprogramming of metabolic dominates neuroblastoma (NB)
progression. It is of great clinical implications to develop an individualized risk …

MYCN is amplified in 20% to 25% of neuroblastoma, and MYCN-amplified neuroblastoma
contributes to a large percent of pediatric cancer–related deaths. Therapy improvements for …