The role of extracellular proteases in cancer progression is well-known, especially in
relation to the promotion of cell invasion through extracellular matrix remodeling. This also …

Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis
and limited treatment options. Serine hydrolases are known to mediate cancer progression …

Proteases are important enzymes in health and disease. Their activities are regulated at
multiple levels. In fact, proteases are synthesized as inactive proenzymes (zymogens) that …

Kallikrein-related peptidases (KLKs) are a family of secreted serine proteases, which form a
network (the KLK activome) with an important role in proteolysis and signaling. In prostate …

Background: CUB domain-containing protein 1 (CDCP1) is a cell surface receptor regulating
key signalling pathways in malignant cells. CDCP1 has been proposed as a molecular …

Activity-based protein profiling enables the specific detection of the active fraction of an
enzyme and is of particular use for the profiling of proteases. The technique relies on a …

Netherton syndrome (NS) is a rare skin disease caused by loss-of-function mutations in the
serine peptidase inhibitor Kazal type 5 (SPINK5) gene. Disease severity and the lack of …

Objective: M6A RNA modification is closely associated with tumor genesis and progression
of several malignancies; however, its role in prostate cancer (PCa) remains poorly …

Pancreatic ductal adenocarcinoma (PDAC) is a growing cause of cancer-related mortality
worldwide. Kallikrein-related peptidase 8 (KLK8) has potential clinical values in many …

Background Communicating hydrocephalus (CH) is a common neurological disorder
caused by a blockage of cerebrospinal fluid. In this study, we aimed to explore the potential …