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[HTML][HTML] Role of zinc homeostasis in the pathogenesis of diabetes and obesity
A Fukunaka, Y Fujitani - International journal of molecular sciences, 2018 - mdpi.com
Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the
underlying molecular mechanisms remained unclear. The breakthrough discovery that the …
underlying molecular mechanisms remained unclear. The breakthrough discovery that the …
Proteolytic degradation of amyloid β-protein
The amyloid β-protein (Aβ) is subject to proteolytic degradation by a diverse array of
peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A …
peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A …
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
Despite decades of speculation that inhibiting endogenous insulin degradation might treat
type-2 diabetes,, and the identification of IDE (insulin-degrading enzyme) as a diabetes …
type-2 diabetes,, and the identification of IDE (insulin-degrading enzyme) as a diabetes …
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance
Recent genome-wide association studies demonstrated that common variants of solute
carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes …
carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes …
Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer's disease?
J. Neurochem.(2012) 120 (Suppl. 1), 167–185. Abstract The amyloid cascade hypothesis of
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …
Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?
Insulin-degrading enzyme (IDE) is a major enzyme responsible for insulin degradation. In
addition to insulin, IDE degrades many targets including glucagon, atrial natriuretic peptide …
addition to insulin, IDE degrades many targets including glucagon, atrial natriuretic peptide …
Brain signaling systems in the type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases
AO Shpakov, KV Derkach, LM Berstein - Future science OA, 2015 - Taylor & Francis
The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases
Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …
Targeting insulin-degrading enzyme in insulin clearance
Hepatic insulin clearance, a physiological process that in response to nutritional cues
clears~ 50–80% of circulating insulin, is emerging as an important factor in our …
clears~ 50–80% of circulating insulin, is emerging as an important factor in our …
Modulation of insulin sensitivity by insulin-degrading enzyme
Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …
metalloprotease that degrades insulin and several other intermediate-size peptides. For …