Acute kidney injury (AKI) is a common and serious problem affecting millions and causing
death and disability for many. In 2012, Kidney Disease: Improving Global Outcomes …

Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …

METHODS The recommendations were developed as a synthesis and update of evidence
from the literature. They are based on the FIGO Safe Motherhood and Newborn Health …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

This executive summary provides the essential treatment algorithms for the resuscitation of
children and adults and highlights the main guideline changes since 2010. Detailed …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Background Hydroxyethyl starch (HES) is widely used for fluid resuscitation in intensive care
units (ICUs), but its safety and efficacy have not been established in patients with severe …

Background The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have
not been fully evaluated, and adverse effects of HES on survival and renal function have …