Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …

Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …

The efficient and timely resolution of DNA recombination intermediates is essential for
bipolar chromosome segregation. Here, we show that the specialized chromosome …

Meiosis is the specialized cell division that generates gametes. In contrast to mitosis,
molecular mechanisms and regulation of meiosis are much less understood. Meiosis shares …

Gamete formation and subsequent offspring development often involve extended phases of
suspended cellular development or even dormancy. How cells adapt to recover and resume …

Ribosome assembly is required for cell growth in all organisms. Classic in vitro work in
bacteria has led to a detailed understanding of the biophysical, thermodynamic, and …

During mitosis, replicated chromosomes (sister chromatids) become attached at the
kinetochore by spindle microtubules emanating from opposite poles and segregate …

Chromosome structure is dynamically regulated during cell division, and this regulation is
dependent, in part, on condensin. The localization of condensin at chromosome arms is …