Rodent models of post-traumatic stress disorder: behavioral assessment

A Verbitsky, D Dopfel, N Zhang - Translational psychiatry, 2020 - nature.com
Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …

The impact of environmental enrichment in laboratory rats—behavioural and neurochemical aspects

J Simpson, JP Kelly - Behavioural brain research, 2011 - Elsevier
The provision of environmental enrichment (EE) for laboratory rats is recommended in
European guidelines governing laboratory animal welfare. It is believed the EE …

Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in …

A Du Preez, D Onorato, I Eiben, K Musaelyan… - Brain, behavior, and …, 2021 - Elsevier
Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …

[HTML][HTML] Citrus limon L.(lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing …

MM Rahman, F Islam, A Parvez, MAK Azad… - Journal of Integrative …, 2022 - imrpress.com
Citrus limon L. is an ingenious alternative medication and has a broad scope in managing
several health conditions as part of natural remedies. Recently, medicinal plants have …

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

F Islam, S Mitra, MH Nafady… - Evidence‐Based …, 2022 - Wiley Online Library
The present study examines the neuropharmacological and antidiabetic properties of
methanol leaves extract of Lannea coromandelica in animal models. This study is carried …

[HTML][HTML] Gut microbiota suppress feeding induced by palatable foods

J Ousey, JC Boktor, SK Mazmanian - Current Biology, 2023 - cell.com
Feeding behaviors depend on intrinsic and extrinsic factors including genetics, food
palatability, and the environment. 1, 2, 3, 4, 5 The gut microbiota is a major environmental …

Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice

SP Patil, PD Jain, PJ Ghumatkar, R Tambe, S Sathaye - Neuroscience, 2014 - Elsevier
Metformin a well known antidiabetic drug has been recently investigated and proposed to
promote neurogenesis and enhance the spatial memory formation. In the present study, we …

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction …

HMA Khalil, HA Eliwa, RA El-Shiekh… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Ashwagandha (ASH) is one of the medicinal plants used
in traditional Indian, Ayurvedic, and Unani medicines for their broad range of …

Serotonin receptor 4 in the hippocampus modulates mood and anxiety

R Karayol, L Medrihan, JL Warner-Schmidt… - Molecular …, 2021 - nature.com
Abstract Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety,
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …

Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: the role of CREB/BDNF and …

S Keshavarzi, S Kermanshahi, L Karami… - Neurotoxicology, 2019 - Elsevier
Background Methamphetamine is a neuro-stimulant with neurodegenerative effects, and
ambiguous mechanism of action. Metformin is an antidiabetic agent with neuroprotective …