Examining the healthy human microbiome concept

R Joos, K Boucher, A Lavelle, M Arumugam… - Nature Reviews …, 2024 - nature.com
Human microbiomes are essential to health throughout the lifespan and are increasingly
recognized and studied for their roles in metabolic, immunological and neurological …

The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes

DP Baars, MF Fondevila, AS Meijnikman… - Cell Host & Microbe, 2024 - cell.com
The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi,
viruses, and bacterial strains. These microorganisms are involved in the fermentation of …

Multikingdom and functional gut microbiota markers for autism spectrum disorder

Q Su, OWH Wong, W Lu, Y Wan, L Zhang, W Xu… - Nature …, 2024 - nature.com
Associations between the gut microbiome and autism spectrum disorder (ASD) have been
investigated although most studies have focused on the bacterial component of the …

The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis

L Zhang, XX Leng, J Qi, N Wang, JX Han, ZH Tao… - Nature …, 2024 - nature.com
Fusobacterium nucleatum can bind to host cells and potentiate intestinal tumorigenesis.
Here we used a genome-wide screen to identify an adhesin, RadD, which facilitates the …

Navigating beyond associations: Opportunities to establish causal relationships between the gut microbiome and colorectal carcinogenesis

FS Baas, N Brusselaers, ID Nagtegaal, L Engstrand… - Cell Host & Microbe, 2024 - cell.com
The gut microbiota has been recognized as an important determinant in the initiation and
progression of colorectal cancer (CRC), with recent studies shining light on the molecular …

[HTML][HTML] Cancer and the Microbiome of the Human Body

L Herrera-Quintana, H Vázquez-Lorente… - Nutrients, 2024 - mdpi.com
Cancer remains a public health concern worldwide, with its incidence increasing worldwide
and expected to continue growing during the next decades. The microbiome has emerged …

[HTML][HTML] Exploring the role of the gut microbiota in modulating colorectal cancer immunity

NK Shakhpazyan, LM Mikhaleva, AL Bedzhanyan… - Cells, 2024 - mdpi.com
The gut microbiota plays an essential role in maintaining immune homeostasis and
influencing the immune landscape within the tumor microenvironment. This review aims to …

Leveraging human microbiomes for disease prediction and treatment

HA Tegegne, TC Savidge - Trends in Pharmacological Sciences, 2024 - cell.com
The human microbiome consists of diverse microorganisms that inhabit various body sites.
As these microbes are increasingly recognized as key determinants of health, there is …

Emerging roles of intratumor microbiota in cancer: tumorigenesis and management strategies

Z Shi, Z Li, M Zhang - Journal of Translational Medicine, 2024 - Springer
The intricate interplay between the host and its microbiota has garnered increasing attention
in the past decade. Specifically, the emerging recognition of microorganisms within diverse …

Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer

L Xu, B Hu, J He, X Fu, N Liu - Frontiers in Pharmacology, 2025 - frontiersin.org
Introduction Colorectal cancer (CRC) is a leading cause of cancer-related mortality globally.
Although tumor immunotherapy is widely recognized for treating unresectable CRC …