Secretase promotes AD progression: simultaneously cleave Notch and APP
KF Yang, JY Zhang, M Feng, K Yao, YY Liu… - Frontiers in Aging …, 2024 - frontiersin.org
Alzheimer's disease (AD) involves complex pathological mechanisms. Secretases include
membrane protein extracellular structural domain proteases and intramembrane proteases …
membrane protein extracellular structural domain proteases and intramembrane proteases …
Mechanism of action and therapeutic targeting of CD30 molecule in lymphomas
Z Li, W Guo, O Bai - Frontiers in Oncology, 2023 - frontiersin.org
At present, the treatment of lymphoma has entered the era of precision medicine, and CD30,
as a transmembrane protein, has become an important marker to help the diagnosis and …
as a transmembrane protein, has become an important marker to help the diagnosis and …
Antibody–Drug Conjugate Made of Zoledronic Acid and the Anti-CD30 Brentuximab–Vedotin Exert Anti-Lymphoma and Immunostimulating Effects
Relevant advances have been made in the management of relapsed/refractory (r/r) Hodgkin
Lymphomas (HL) with the use of the anti-CD30 antibody–drug conjugate (ADC) …
Lymphomas (HL) with the use of the anti-CD30 antibody–drug conjugate (ADC) …
ADAM10-a “multitasker” in sepsis: Focus on its posttranslational target
S Liao, Y Lin, L Liu, S Yang, YY Lin, J He… - Inflammation Research, 2023 - Springer
Background Sepsis has a complex pathogenesis in which the uncontrolled systemic
inflammatory response triggered by infection leads to vascular barrier disruption …
inflammatory response triggered by infection leads to vascular barrier disruption …
The Biology of Classical Hodgkin Lymphoma
S Kosydar, SM Ansell - Seminars in Hematology, 2024 - Elsevier
Classical Hodgkin lymphoma (cHL) is distinguished by several important biological
characteristics. The presence of Hodgkin Reed Sternberg (HRS) cells is a defining feature of …
characteristics. The presence of Hodgkin Reed Sternberg (HRS) cells is a defining feature of …
Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization
Matrix metalloproteinase 13 plays a central role in osteoarthritis (OA), as its overexpression
induces an excessive breakdown of collagen that results in an imbalance between collagen …
induces an excessive breakdown of collagen that results in an imbalance between collagen …
Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives
Human deaths caused by Gram-negative bacteria keep rising due to the multidrug
resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with …
resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with …
[HTML][HTML] Antibody–Drug Conjugates Targeting CD30 in T-Cell Lymphomas: Clinical Progression and Mechanism
Y Jiang, S Dong, Y Wang - Cancers, 2025 - mdpi.com
CD30 is overexpressed in many T-cell lymphoma (TCL) entities, including subsets of
peripheral T-cell lymphomas (PTCL) and cutaneous T-cell lymphomas (CTCL). The antibody …
peripheral T-cell lymphomas (PTCL) and cutaneous T-cell lymphomas (CTCL). The antibody …
Targeting secretory autophagy in solid cancers: mechanisms, immune regulation and clinical insights
X Li, H Zhao - Experimental Hematology & Oncology, 2025 - Springer
Secretory autophagy is a classical form of unconventional secretion that integrates
autophagy with the secretory process, relying on highly conserved autophagy-related …
autophagy with the secretory process, relying on highly conserved autophagy-related …
ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
D Van Meenen, A Doege, E Alefeld, A Haase… - International journal of …, 2022 - mdpi.com
A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are
important factors in a number of pathologies, including cancer, and have been suggested as …
important factors in a number of pathologies, including cancer, and have been suggested as …