Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents

A Angelova, VM Garamus, B Angelov, Z Tian… - Advances in colloid and …, 2017 - Elsevier
The present work highlights recent achievements in development of nanostructured
dispersions and biocolloids for drug delivery applications. We emphasize the key role of …

Micro and nano-scale compartments guide the structural transition of silk protein monomers into silk fibers

D Eliaz, S Paul, D Benyamin, A Cernescu… - Nature …, 2022 - nature.com
Silk is a unique, remarkably strong biomaterial made of simple protein building blocks. To
date, no synthetic method has come close to reproducing the properties of natural silk, due …

Insight into structural biophysics from solution X-ray scattering

U Raviv, R Asor, A Shemesh, A Ginsburg… - Journal of Structural …, 2023 - Elsevier
The current challenges of structural biophysics include determining the structure of large self-
assembled complexes, resolving the structure of ensembles of complex structures and their …

Structure of sodium carboxymethyl cellulose aqueous solutions: A SANS and rheology study

CG Lopez, SE Rogers, RH Colby… - Journal of Polymer …, 2015 - Wiley Online Library
We report a small angle neutron scattering (SANS) and rheology study of cellulose
derivative polyelectrolyte sodium carboxymethyl cellulose with a degree of substitution of …

Using solution X-ray scattering to determine the high-resolution structure and morphology of PEGylated liposomal doxorubicin nanodrugs

Y Schilt, T Berman, X Wei, Y Barenholz… - Biochimica et Biophysica …, 2016 - Elsevier
Abstract Background Among nanodrugs, PEGylated nanoliposomes loaded with an active
agent are of major importance. In this paper we studied the structures and morphology of …

RNA encapsidation by SV40-derived nanoparticles follows a rapid two-state mechanism

S Kler, R Asor, C Li, A Ginsburg, D Harries… - Journal of the …, 2012 - ACS Publications
Remarkably, uniform virus-like particles self-assemble in a process that appears to follow a
rapid kinetic mechanism. The mechanisms by which spherical viruses assemble from …

Shape and interhelical spacing of DNA origami nanostructures studied by small-angle X-ray scattering

S Fischer, C Hartl, K Frank, JO Rädler, T Liedl… - Nano …, 2016 - ACS Publications
Scaffolded DNA origami nanostructures enable the self-assembly of arbitrarily shaped
objects with unprecedented accuracy. Yet, varying physiological conditions are prone to …

Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: relating structure and pharmacokinetics to therapeutic efficacy

D Zucker, AV Andriyanov, A Steiner, U Raviv… - Journal of controlled …, 2012 - Elsevier
Recently, develo** drug delivery systems exhibiting controlled drug release at the tumor
sites emerged as an attractive option for enhancing anticancer therapeutic efficacy. It seems …

Assembly reactions of hepatitis B capsid protein into capsid nanoparticles follow a narrow path through a complex reaction landscape

R Asor, L Selzer, CJ Schlicksup, Z Zhao, A Zlotnick… - ACS …, 2019 - ACS Publications
For many viruses, capsids (biological nanoparticles) assemble to protect genetic material
and dissociate to release their cargo. To understand these contradictory properties, we …

Vesicle adhesion and fusion studied by small-angle X-ray scattering

K Komorowski, A Salditt, Y Xu, H Yavuz, M Brennich… - Biophysical …, 2018 - cell.com
We have studied the adhesion state (also denoted by docking state) of lipid vesicles as
induced by the divalent ions Ca 2+ or Mg 2+ at well-controlled ion concentration, lipid …