The 2022 report on the human proteome from the HUPO human proteome project

GS Omenn, L Lane, CM Overall, C Pineau… - Journal of proteome …, 2022 - ACS Publications
The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP)
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …

The glycosaminoglycan interactome 2.0

SD Vallet, C Berthollier… - American Journal of …, 2022 - journals.physiology.org
Glycosaminoglycans (GAGs) are complex linear polysaccharides, which are covalently
attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles …

UniProt: the universal protein knowledgebase in 2023

Nucleic acids research, 2023 - academic.oup.com
The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-
quality and freely accessible set of protein sequences annotated with functional information …

[HTML][HTML] Information fusion as an integrative cross-cutting enabler to achieve robust, explainable, and trustworthy medical artificial intelligence

A Holzinger, M Dehmer, F Emmert-Streib, R Cucchiara… - Information …, 2022 - Elsevier
Medical artificial intelligence (AI) systems have been remarkably successful, even
outperforming human performance at certain tasks. There is no doubt that AI is important to …

The IntAct database: efficient access to fine-grained molecular interaction data

N Del Toro, A Shrivastava, E Ragueneau… - Nucleic acids …, 2022 - academic.oup.com
The IntAct molecular interaction database (https://www. ebi. ac. uk/intact) is a curated
resource of molecular interactions, derived from the scientific literature and from direct data …

The STRING database in 2025: protein networks with directionality of regulation

D Szklarczyk, K Nastou, M Koutrouli… - Nucleic Acids …, 2025 - academic.oup.com
Proteins cooperate, regulate and bind each other to achieve their functions. Understanding
the complex network of their interactions is essential for a systems-level description of …

IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis

M Kotlyar, C Pastrello, Z Ahmed, J Chee… - Nucleic acids …, 2022 - academic.oup.com
Improved bioassays have significantly increased the rate of identifying new protein-protein
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …

Network expansion of genetic associations defines a pleiotropy map of human cell biology

I Barrio-Hernandez, J Schwartzentruber… - Nature Genetics, 2023 - nature.com
Interacting proteins tend to have similar functions, influencing the same organismal traits.
Interaction networks can be used to expand the list of candidate trait-associated genes from …

Proteomics standards initiative at twenty years: current activities and future work

EW Deutsch, JA Vizcaíno, AR Jones… - Journal of proteome …, 2023 - ACS Publications
The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been
successfully develo** guidelines, data formats, and controlled vocabularies (CVs) for the …

UniProt and mass spectrometry-based proteomics—a 2-way working relationship

EH Bowler-Barnett, J Fan, J Luo, M Magrane… - Molecular & Cellular …, 2023 - mcponline.org
The human proteome comprises of all of the proteins produced by the sequences translated
from the human genome with additional modifications in both sequence and function caused …