RNA helicases of the DEAD box family are present in all eukaryotic cells and in many
bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism …

RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all
aspects of RNA metabolism. These proteins bind or remodel RNA or RNA–protein …

James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …

Group II introns are mobile ribozymes that self-splice from precursor RNAs to yield excised
intron lariat RNAs, which then invade new genomic DNA sites by reverse splicing. The …

Ribozymes are catalytic RNAs with diverse functions including self-splicing and
polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and …

Helicases and remodeling enzymes are ATP-dependent motor proteins that play a critical
role in every aspect of RNA and DNA metabolism. Most RNA-remodeling enzymes are …

Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily
broad set of functional roles. Central among these roles are the promotion of …

RNA molecules face difficulties when folding into their native structures. In the cell, proteins
can assist RNAs in reaching their functionally active states by binding and stabilizing a …

RNA helicases are a large group of enzymes that function in virtually all aspects of RNA
metabolism. Although RNA helicases share a highly conserved structure, different enzymes …

The pentatricopeptide repeat (PPR) is a degenerate 35–amino acid repeat motif that is
widely distributed among eukaryotes. Genetic, biochemical, and bioinformatic data suggest …