Decoding hepatocarcinogenesis from a noncoding RNAs perspective

MKA El‐Aziz, A Dawoud, CJ Kiriacos… - Journal of cellular …, 2023 - Wiley Online Library
Being a leading lethal malignancy worldwide, the pathophysiology of hepatocellular
carcinoma (HCC) has gained a lot of interest. Yet, underlying mechanistic basis of the liver …

Recent advances in tannic acid (gallotannin) anticancer activities and drug delivery systems for efficacy improvement; a comprehensive review

R A. Youness, R Kamel, N A. Elkasabgy, P Shao… - Molecules, 2021 - mdpi.com
Tannic acid is a chief gallo-tannin belonging to the hydrolysable tannins extracted from gall
nuts and other plant sources. A myriad of pharmaceutical and biological applications in the …

Targets involved in the anti-cancer activity of quercetin in breast, colorectal and liver neoplasms

A Maugeri, A Calderaro, GT Patanè, M Navarra… - International Journal of …, 2023 - mdpi.com
Phytochemicals have long been effective partners in the fight against several diseases,
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …

Current insights into epigenetics, noncoding RNA interactome and clinical pharmacokinetics of dietary polyphenols in cancer chemoprevention

D Shah, M Gandhi, A Kumar… - Critical reviews in …, 2023 - Taylor & Francis
Several studies have reported the health-beneficial effects of dietary phytochemicals,
namely polyphenols, to prevent various diseases, including cancer. Polyphenols, like (−) …

Emerging role of circular RNAs in hepatocellular carcinoma immunotherapy

T Abaza, MKA El-Aziz, KA Daniel, P Karousi… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is a highly fatal malignancy with limited therapeutic options
and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint …

Molecular engines, therapeutic targets, and challenges in pediatric brain tumors: a special emphasis on hydrogen sulfide and RNA-based nano-delivery

SA Fahmy, A Dawoud, YA Zeinelabdeen, CJ Kiriacos… - Cancers, 2022 - mdpi.com
Simple Summary Pediatric brain tumors represent a formidable challenge in the field of
oncology. Pediatric brain tumors are sub-classified into several molecular sub-types, where …

Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis

X Ma, X Yang, W Bao, S Li, S Liang, Y Sun… - Biochemical and …, 2018 - Elsevier
Lung cancer remains a leading cause of cancer-related deaths worldwide. In the past years,
increasing reports indicate that circular RNAs (circRNAs) exert a great important role in …

[HTML][HTML] Long non-coding RNAs: functional regulatory players in breast cancer

RA Youness, MZ Gad - Non-coding RNA research, 2019 - Elsevier
Historically, the long-held protein-centered bias has denoted 98% of the human genome as
'Junk'DNA. However, the current work has shifted the perception of such'junk'transcriptional …

MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin glycoside alters immunogenic and oncogenic profiles of breast cancer

M Abdel-Latif, A Riad, RA Soliman, AM Elkhouly… - Molecular and Cellular …, 2022 - Springer
Abstract Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC
subtypes. Our research group has recently shed the light on the utility of natural compounds …

Phytochemical-derived tumor-associated macrophage remodeling strategy using Phoenix dactylifera L. boosted photodynamic therapy in melanoma via H19/iNOS/PD …

AH Soliman, RA Youness, AA Sebak… - Photodiagnosis and …, 2023 - Elsevier
Background The tumor microenvironment (TME) represents a barrier to PDT efficacy among
melanoma patients. The aim of this study is to employ a novel muti-tactic TME-remodeling …