Vaccines are one of the most important tools in public health and play an important role in
infectious diseases control. Owing to its precision, safe profile and flexible manufacturing …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and
cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development …

This review will explore the four major pillars required for design and development of an
saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and …

Abstract mRNA vaccines have become a versatile technology for the prevention of infectious
diseases and the treatment of cancers. In the vaccination process, mRNA formulation and …

The current COVID-19 epidemic has greatly accelerated the application of mRNA
technology to our real world, and during this battle mRNA has proven it's unique advantages …

Self-amplifying RNA (saRNA) is a cutting-edge platform for both nucleic acid vaccines and
therapeutics. saRNA is self-adjuvanting, as it activates types I and III interferon (IFN), which …

Abstract Currently, messenger RNA (mRNA)-based lipid nanoparticle formulations
revolutionize the clinical field. Cationic polymer-based complexes (polyplexes) represent an …

This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

Loss of sweat glands (SwGs) commonly associated with extensive skin defects is a leading
cause of hyperthermia and heat stroke. In vivo tissue engineering possesses the potential to …