HFIP-Mediated, Highly Chemo-, Regio-, and Stereoselective Hydrofunctionalizations of Ynamides: Access to Stereodefined Alkenes Bearing Drugs and Natural …
We disclose a sustainable and versatile synthetic strategy for the highly chemo-, regio-, and
stereoselective hydrofunctionalizations of ynamides, through its activation by a solvent …
stereoselective hydrofunctionalizations of ynamides, through its activation by a solvent …
Catalytic intermolecular hydrofunctionalizations of ynamides
YY Zhao, YJ Jia, Y Hu - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
Ynamides are electron-rich alkynes with a carbon–carbon triple bond directly attached to the
nitrogen atom bearing an electron-withdrawing group. This unique structure renders diverse …
nitrogen atom bearing an electron-withdrawing group. This unique structure renders diverse …
A 6-endo-dig Thiolative Cyclization of Yne-Ynamides: Access to Thiodihydropyridin-2-ones
A straightforward regioselective intramolecular 6-endo-dig cyclization of yne-tethered
ynamide is herein developed. The reaction involves an intramolecular enolate attack of …
ynamide is herein developed. The reaction involves an intramolecular enolate attack of …
Gold (i)-catalysed cyclisation of (E)-ketene-N, O-acetals: a synthetic route toward spiro-oxazole-γ-lactones
In this study, we developed a cascade 5, 5-cyclisation of internal ketene-N, O-acetals
utilizing homogeneous Au (I) catalysis. This process involves an initial 5-exo-dig …
utilizing homogeneous Au (I) catalysis. This process involves an initial 5-exo-dig …
HFIP-Mediated, Regio-, and Stereoselective Hydrosulfenylation of Ynamides: A Versatile Strategy to Access Ketene N, S-Acetals
Herein, we report a HFIP-mediated, versatile, sustainable, atom-economic, and regio-, and
stereoselective hydro-functionalization of ynamides with various S-nucleophiles (1 equiv) …
stereoselective hydro-functionalization of ynamides with various S-nucleophiles (1 equiv) …