According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

In the life sciences, a new paradigm is emerging that places networks of interacting
molecules between genotype and phenotype. These networks are dynamically modulated …

Chemical probes are critical tools for elucidating the biological functions of proteins and can
lead to new medicines for treating disease. The pharmacological validation of protein …

Kinase networks are important for cellular signal transduction. Despite tremendous efforts to
uncover these signaling pathways, huge numbers of uncharacterized phosphosites still …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Advances in the generation and interpretation of proteomics data have spurred a transition
from focusing on protein identification to functional analysis. Here we review recent …

Reversible protein phosphorylation serves as a basis for regulating a number of cellular
processes. Aberrant activation of kinase signaling pathways is commonly associated with …

Although we have made great progress in understanding the complex genetic alterations
that underlie human cancer, it has proven difficult to identify which molecularly targeted …

Spatiotemporal detection of proteins in living cells is a persistent challenge but is the key to
understanding their cellular biology and develo** theranostic technologies. We develop a …

Mass spectrometry has evolved at an exponential rate over the last 100 years. Innovations in
the development of mass spectrometers have created powerful instruments capable of …