Cardiovascular disease is a leading cause of death worldwide, and thus there remains great
interest in regenerative approaches to treat heart failure. In the past 20 years, the field of …

The heart is a very complex conglomeration of organized interactions between various
different cell types that all aid in facilitating myocardial function through contractility, sufficient …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

The reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) raises the
possibility that a somatic cell could be reprogrammed to an alternative differentiated fate …

Abstract Background Extracellular vesicles (EVs) and exosomes are nano-sized, membrane-
bound vesicles shed by most eukaryotic cells studied to date. EVs play key signaling roles in …

Rationale: Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy.
Most prominent among these are direct heart muscle and blood vessel regeneration from …

Objectives: The goal of this study was to conduct a direct head-to-head comparison of
different stem cell types in vitro for various assays of potency and in vivo for functional …

Abstract Aims Cardiosphere-derived cells (CDCs) are cardiac progenitor cells that exhibit
disease-modifying bioactivity in various models of cardiomyopathy and in previous clinical …

Background—Cardiosphere-derived cells (CDCs) are an attractive cell type for tissue
regeneration, and autologous CDCs are being tested clinically. However, autologous …

Myocardial regeneration using stem and progenitor cell transplantation in the injured heart
has recently become a major goal in the treatment of cardiac disease. Experimental studies …