Blood-spinal cord barrier disruption in degenerative cervical myelopathy

HW Kim, H Yong, GKH Shea - Fluids and Barriers of the CNS, 2023 - Springer
Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord
dysfunction in the aging population. Significant neurological deficits may result from a …

Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression

M Yao, P Pu, Z Li, K Zhu, L Zhou, YL Sun… - Journal of pineal …, 2023 - Wiley Online Library
Cervical spondylotic myelopathy (CSM) refers to a chronic injury of the cervical cord caused
by cervical intervertebral disc degeneration. Endoplasmic reticulum (ER) homeostasis is …

Chronic spinal cord compression associated with intervertebral disc degeneration in SPARC-null mice

ZY Li, AF Zhou, G Li, LY Zhou, PM Pu… - Neural Regeneration …, 2023 - journals.lww.com
Chronic spinal cord compression (CSCC) is induced by disc herniation and other reasons,
leading to movement and sensation dysfunction, with a serious impact on quality of life …

[HTML][HTML] Network pharmacology analysis and animal experiment validation of neuroinflammation inhibition by total ginsenoside in treating CSM

Z Li, Y Dai, Z Wu, G Li, P Pu, C Hu, L Zhou, K Zhu… - Phytomedicine, 2024 - Elsevier
Background Cervical spondylotic myelopathy (CSM) is a degenerative pathology that affects
both upper and lower extremity mobility and sensory function, causing significant pressure …

Shenqisherong pill ameliorates neuronal apoptosis by inhibiting the JNK/caspase-3 signaling pathway in a rat model of cervical cord compression

K Zhu, P Pu, G Li, L Zhou, Z Li, Q Shi, Y Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance The Shenqisherong (SQSR) pill is an empirical
prescription of traditional Chinese medicine (TCM), which originated from the National …

Shikonin inhibits endoplasmic reticulum stress-induced apoptosis to attenuate renal ischemia/reperfusion injury by activating the SIRT1/Nrf2/HO-1 pathway

Q Huang, Z Shi, D Zheng, H Chen… - Kidney and Blood Pressure …, 2025 - karger.com
Introduction: Shikonin is the major bioactive compound abundant in Lithospermum
erythrorhizon and possesses diverse pharmacological properties. This study aimed to …

Ischemia–reperfusion injury after spinal cord decompressive surgery—An in vivo rat model

B Zhang, Z **, P Luo, H Yin, X Chen… - Animal Models and …, 2024 - Wiley Online Library
Background Although decompression surgery is the optimal treatment for patients with
severe degenerative cervical myelopathy (DCM), some individuals experience no …

[HTML][HTML] Analysis of gene expression profiles and experimental validations of a rat chronic cervical cord compression model

P Pu, Z Li, Y Dai, Y Sun, Y Wang, X Cui… - Neurochemistry …, 2023 - Elsevier
Cervical spondylotic myelopathy (CSM) is a severe non-traumatic spinal cord injury (SCI)
wherein the spinal canal and cervical cord are compressed due to the degeneration of …

Finite element biomechanical analysis of minimally invasive treatment of cervical spondylotic myelopathy and accurate exercise rehabilitation

J Liu, H Zhang, H Cui, L Pan, B Zhao, F Li… - Chinese Journal of Tissue …, 2023 - cjter.com
BACKGROUND: Endoscopic fenestration and decompression of cervical lamina lead to
changes in bony structure of cervical vertebrae, which in turn leads to biomechanical …

Natural agents that are neuroprotective against mitochondria: a bibliometric-based research map** 1998–2024, from cells to mitochondria

A YURISALDI SALEH, DA Yogi Saputra - F1000Research, 2024 - f1000research.com
Introduction Mitochondria are cell organelles that function as the cell's main power plant,
producing ATP, the main energy molecule in cells. Mitochondria play an important role in the …