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Large-conductance, calcium-activated potassium channels: structural and functional implications
S Ghatta, D Nimmagadda, X Xu, ST O'Rourke - Pharmacology & …, 2006 - Elsevier
The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …
Regulation of BK channels by beta and gamma subunits
Ca2+-and voltage-gated K+ channels of large conductance (BK channels) are expressed in
a diverse variety of both excitable and inexcitable cells, with functional properties …
a diverse variety of both excitable and inexcitable cells, with functional properties …
Functional significance of channels and transporters expressed in the inner ear and kidney
A number of ion channels and transporters are expressed in both the inner ear and kidney.
In the inner ear, K+ cycling and endolymphatic K+, Na+, Ca2+, and pH homeostasis are …
In the inner ear, K+ cycling and endolymphatic K+, Na+, Ca2+, and pH homeostasis are …
The distal convoluted tubule
The distal tubule of the mammalian kidney can be defined as the nephron segment between
the macula densa region and the cortical collecting tubule. It comprises several …
the macula densa region and the cortical collecting tubule. It comprises several …
A comprehensive guide to the ROMK potassium channel: form and function in health and disease
The discovery of the renal outer medullary K+ channel (ROMK, Kir1. 1), the founding
member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 …
member of the inward-rectifying K+ channel (Kir) family, by Ho and Hebert in 1993 …
Large conductance voltage-and calcium-activated K+ (BK) channel in health and disease
Large Conductance Voltage-and Calcium-activated K+ (BK) channels are transmembrane
pore-forming proteins that regulate cell excitability and are also expressed in non-excitable …
pore-forming proteins that regulate cell excitability and are also expressed in non-excitable …
Sensing of tubular flow and renal electrolyte transport
EHJ Verschuren, C Castenmiller, DJM Peters… - Nature Reviews …, 2020 - nature.com
The kidney is a remarkable organ that accomplishes the challenge of removing waste from
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …
Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells
Gain/loss of function studies were utilized to assess the potential role of the endogenous
vanilloid receptor TRPV4 as a sensor of flow and osmolality in M-1 collecting duct cells …
vanilloid receptor TRPV4 as a sensor of flow and osmolality in M-1 collecting duct cells …
Aldosterone, SGK1, and ion channels in the kidney
Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+,
and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active …
and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active …
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms
WNK kinases are serine-threonine kinases with an atypical placement of the catalytic lysine.
Intronic deletions with increased expression of a ubiquitous long WNK1 transcript cause …
Intronic deletions with increased expression of a ubiquitous long WNK1 transcript cause …